The authors of one new study out of University of Michigan seem to think so.  As someone who suffers from nausea via virtually anything that moves, I find this to be a depressing prospect for what could otherwise be an environmentally beneficial technology (reducing car ownership and improving vehicle efficiency).

I’m in the minority though:

The results indicate that, for example, 6%-10% of American adults riding in fully self-driving vehicles would be expected to often, usually, or always experience some level of motion sickness. Analogously, 6%-12% of American adults riding in fully self-driving vehicles would be expected to experience moderate or severe motion sickness at some time.

I guess reading a book or checking email while a self-driving car jerks you around in unpredictable ways is not a recipe for keeping down your lunch. At least for the unlucky 6-12% of us.